Antifungal medications are the standard treatment for a vaginal yeast infection. You can insert a cream or suppository antifungal cream into your vagina or take a pill by mouth. Vaginal boric acid capsules are an alternative treatment that is gaining wider use for treating vaginal yeast infections.⁵

Antifungal medications you take as a pill by mouth affect the entire body (so it can also treat any yeast infection elsewhere in the body); vaginal medication only affects the area in which it is applied. During pregnancy, only vaginal treatment is considered safe.

If you are considering nonprescription treatment, see:

Should I use a nonprescription medication for a vaginal yeast infection?

Medication Choices

• Vaginal antifungal medications are available in 1-day, 3-day, and longer courses, depending on the strength of the medication.
• Oral antifungal medications are easy to use but are not prescribed to pregnant women.
• Vaginal boric acid capsules (600mg boric acid in a size 00 gelatin capsule) are used once daily for 2 weeks.

What To Think About

Antifungal creams and suppositories that you put into your vagina have fewer side effects than antifungal pills you take by mouth. This is because vaginal medication isn't absorbed into your body and only affects the genital area. Antifungal pills that are taken by mouth affect your entire body. Side effects from these pills are rare with one treatment dose, but they can include nausea, headaches, and abdominal pain. However, taking a pill is convenient and is not messy. Medicine put into the vagina can be uncomfortable, and it may seem like more of a hassle than taking a pill.

Do not trust a condom or diaphragm for birth control when using an antifungal cream or suppository. Many of the vaginal creams and suppositories used to treat yeast infections are oil-based, which can weaken rubber (latex).

If you are taking the anticoagulant medication warfarin and you use a nonprescription vaginal yeast-fighting medication, such as Monistat, you may have increased bruising and abnormal bleeding. Talk with your health professional before using an antifungal medication along with warfarin.

You are more likely to use a treatment correctly and complete the treatment if you get to choose the type you prefer. Talk with your health professional about the advantages and disadvantages of vaginal and oral medications, including:

• How a medication can be administered. Most of the vaginal treatments are available as creams, vaginal tablets, or suppositories.
• Whether oral or vaginal medication is recommended. You may prefer to take pills rather than use medication that is inserted into the vagina, or the type of yeast infection you have may respond better to one method than the other.
• Whether you should avoid sexual intercourse if you are using vaginal medication. Some health professionals advise that women avoid sex during treatment.
• Whether treatment should be continued during your menstrual period. Tampons can absorb medication, so use sanitary napkins if you are being treated with vaginal medications during your period.

Check with your doctor or pharmacist to see whether you can get a generic form of a prescription medicine. Many generic medicines are now available to treat vaginal yeast infections. They are often less expensive than brand-name medicines.