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Pap Test: Collecting Cells in Liquid - Topic Overview

Liquid-based methods for collecting cervical cells and preparing them for laboratory evaluation are now available.

A sample of cervical cells is collected during a Pap test, and the cells are then rinsed in a liquid vial instead of being smeared on slides. The vials are taken to the laboratory, and a thin layer of the specimen is put on slides for microscopic examination. Only a small portion of the sample is used for the slide, so the remainder of the cell sample can be used for any further testing, such as a human papillomavirus (HPV) test.

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These methods can produce false-positive results just like standard Pap tests. Not all laboratories provide this testing, but liquid-based methods are becoming more widely used. These methods cost more than standard Pap testing.

WebMD Medical Reference from Healthwise

Last Updated: December 28, 2010

This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.