Depression is a symptom that many
women experience during their menstruating years. The key element that sets
apart PMS-related depression from other forms of depression is the timing of
symptoms. More than 150 different symptoms have been ascribed to PMS, but the
hallmark of PMS-related problems is their occurrence during the two weeks prior
to the onset of menstruation (around the time
of ovulation). Women suffering
from PMS-related depression report dramatic relief from their symptoms...
PMS symptoms are severe and regularly disrupt
her quality of life.
She has no future plans to have biological
children, and she is many years away from natural
Symptoms improve with the use of medicines that produce
a condition similar to
menopause (such as danazol or a gonadotropin-releasing
hormone agonist [GnRH-a]). But even if symptoms improve during danazol or a
GnRH-a treatment, it is possible that the medicine is not the reason for the
All other treatments have failed.
All or most of the symptoms are directly related to PMDD. Other
problems, such as psychological or nonmedical problems in her life or
environment, do not appear to contribute to the symptoms.
Although oophorectomy ends premenstrual symptoms, it also
leads to early menopause and
perimenopausal symptoms that tend to be more severe
than those of natural menopause. Early menopause also increases the risk of
osteoporosis because low estrogen leads to bone
density loss. Because of this, women with no ovaries are advised to take
estrogen (HRT or ERT) at least until menopausal age to protect
against bone loss.