Mittelschmerz
Mittelschmerz Overview
Mittelschmerz (pronounced MITT-ul-shmurz) is a German word that means middle pain. This pain occurs during ovulation—the midpoint between menstrual periods, about 2 weeks before a period may begin. The discomfort can appear on either side of the lower abdomen depending on which ovary is producing the ovum (egg). Pain can be on one side of the abdomen one month and switch to the opposite side during the following cycle. About 20% of women experience this type of midcycle pain. Most of the time, it is a mild annoyance. In rare instances, it can be unbearable.
Mittelschmerz Causes
Just before the egg is released by the ovary, it stretches the membrane covering the ovary. This stretching results in pressure and pain. The fluid and blood released when the egg is released from the ovary may cause discomfort. Blood is very irritating to the tissues lining the abdominal cavity and could be responsible for the midcycle pain. The amount of pain varies tremendously from person to person. Most women do not have any discomfort. Others feel a mild pressure or twinge lasting a few hours. For a rare few, the pain is intense and can last for days. In severe cases, the pain may be mistaken for appendicitis.
Mittelschmerz Symptoms
Pain associated with mittelschmerz may take on various forms:
- Pain occurs on one side of the lower abdomen (can be either side).
- Pain occurs midway between menstrual periods (during ovulation).
- Pain can occur every month.
- Pain lasts anywhere from a few hours to 2-3 days.
When to Seek Medical Care
Women with mittelschmerz rarely need to go to a hospital's emergency
department, but some serious medical conditions such as appendicitis
and ectopic
pregnancy can mimic the pain of ovulation. A woman should go to the
emergency department if it is possible one of these conditions is causing the
pain.
- Appendicitis causes pain in the lower right side of the abdomen along with
loss of appetite, nausea,
or vomiting.
- An ectopic pregnancy is a pregnancy that develops in the fallopian tube instead of the uterus. This might be the cause of the pain if the woman thinks she might be pregnant or if her last menstrual period was irregular.
A woman should call her doctor if the following occur:
- Midcycle pain lasts longer than 3 days
- Vaginal bleeding occurs during midcycle pain
Exams and Tests
No specific test can determine if a woman has mittelschmerz. It is a diagnosis of exclusion—meaning the doctor will do tests to make sure no other medical problems exist. The diagnosis is confirmed if the test results are normal and the pain is typical for midcycle pain. The doctor may ask the woman to keep a diary of her menstrual cycles to determine if the pain occurs at midcycle.
WebMD Medical Reference from eMedicineHealth
VIVELLE-DOT (estradiol transdermal system) IS AVAILABLE BY PRESCRIPTION ONLY.
INDICATION
Vivelle-Dot is used after menopause to: reduce moderate to severe hot flashes; treat moderate to severe dryness, itching and burning in or around the vagina; help reduce your chances of getting osteoporosis (thin weak bones); and treat certain conditions in which a young woman's ovaries do not produce enough estrogens naturally. Vivelle-Dot 0.025 mg/day is only used to prevent osteoporosis from menopause. If you use Vivelle-Dot only to treat your dryness, itching, and burning in and around your vagina or if you use Vivelle-Dot only to prevent osteoporosis from menopause, talk with your healthcare professional about whether a different treatment or medicine without estrogens might be better for you.
IMPORTANT SAFETY INFORMATION
Estrogens increase the chances of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are taking estrogens. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb).
Do not use estrogens with or without progestins to prevent heart disease, heart attacks, or strokes. Using estrogens with or without progestins may increase your chances of getting heart attacks, strokes, breast cancer, and blood clots. Using estrogens with progestins may increase your risk of dementia (decline in memory and thinking skills).
Vivelle-Dot should not be used if you have unusual vaginal bleeding; currently have or have had certain cancers, including cancer of the breast or uterus; had a stroke or heart attack in the recent past (for example, in the past year); currently have or have had blood clots; currently have or have had liver problems; or think you may be, or know that you are, pregnant.
The most common side effects that may occur with Vivelle-Dot are headache, breast tenderness, and back pain.
You and your healthcare professional should talk regularly about whether you still need treatment with Vivelle-Dot.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
Please see Full Prescribing Information for Vivelle-Dot.

